Acute Kidney Injury Leading to CKD is Associated with a Persistence of Metabolic Dysfunction and Hypertriglyceridemia A Harzandi, G Bidkhori, S Lee, S Saha, B Hendry, A Mardinoglu, S Shoaie, ...Available at SSRN 3708521
Applications of Genome-Wide Screening and Systems Biology Approaches in Drug Repositioning E Mohammadi, R Benfeitas, H Turkez, J Boren, J Nielsen, M Uhlen, ... Cancers 12 (9), 2694
Systems Biology Approaches to Understand the Host–Microbiome Interactions in Neurodegenerative Diseases D Rosario, J Boren, M Uhlen, G Proctor, D Aarsland, A Mardinoglu, ... Frontiers in Neuroscience 14, 716
A systems biology approach for studying neurodegenerative diseases S Lam, A Bayraktar, C Zhang, H Turkez, J Nielsen, J Boren, S Shoaie, ... Drug Discovery Today
In vitro neuroprotective effects of farnesene sesquiterpene on alzheimer’s disease model of differentiated neuroblastoma cell line ME Arslan, H Türkez, A Mardinoğlu International Journal of Neuroscience, 1-10
Neuroprotective effects of boron nitride nanoparticles in the experimental Parkinson’s disease model against MPP+ induced apoptosis R Küçükdoğru, H Türkez, ME Arslan, ÖÖ Tozlu, E Sönmez, A Mardinoğlu, ... Metabolic Brain Disease, 1-11
An atlas of human metabolism JL Robinson, P Kocabaş, H Wang, PE Cholley, D Cook, A Nilsson, ... Science Signaling 13 (624)
Nonpharmacological treatment options for Alzheimer's disease: from animal testing to clinical studies H TÜRKEZ, ME Arslan, A Di Stefano, I Cacciatore, A MARDİNOĞLU Turkish Journal of Zoology 44 (2), 81-89
Classification of clear cell renal cell carcinoma based on PKM alternative splicing X Li, B Turanli, K Juszczak, W Kim, M Arif, Y Sato, S Ogawa, H Turkez, ... Heliyon 6 (2), e03440
Novel anti-Alzheimer phenol-lipoyl hybrids: Synthesis, physico-chemical characterization, and biological evaluation A Pagoni, L Marinelli, A Di Stefano, M Ciulla, H Turkez, A Mardinoglu, ... European Journal of Medicinal Chemistry 186, 111880
Systems biology based drug repositioning for development of cancer therapy B Turanli, O Altay, J Borén, H Turkez, J Nielsen, M Uhlen, KY Arga, ... Seminars in Cancer Biology
Discovery of functional alternatively spliced PKM transcripts in human cancers X Li, C Zhang, W Kim, M Arif, C Gao, A Hober, D Kotol, L Strandberg, ... BioRxiv, 613364
A network-based cancer drug discovery: from integrated multi-omics approaches to precision medicine B Turanli, K Karagoz, G Gulfidan, R Sinha, A Mardinoglu, KY Arga Current pharmaceutical design 24 (32), 3778-3790
Systems biology in hepatology: approaches and applications A Mardinoglu, J Boren, U Smith, M Uhlen, J Nielsen Nature Reviews Gastroenterology & Hepatology 15, 365–377
A pathology atlas of the human cancer transcriptome M Uhlen, C Zhang, S Lee, E Sjöstedt, L Fagerberg, G Bidkhori, ... Science 357 (6352)
Transcriptomics resources of human tissues and organs M Uhlén, BM Hallström, C Lindskog, A Mardinoglu, F Pontén, J Nielsen Molecular systems biology 12 (4), 862
The gut microbiota modulates host amino acid and glutathione metabolism in mice A Mardinoglu, S Shoaie, M Bergentall, P Ghaffari, C Zhang, E Larsson, ... Molecular systems biology 11 (10), 834
Quantifying diet-induced metabolic changes of the human gut microbiome S Shoaie, P Ghaffari, P Kovatcheva-Datchary, A Mardinoglu, P Sen, ... Cell metabolism 22 (2), 320-331
New paradigms for metabolic modeling of human cells A Mardinoglu, J Nielsen Current opinion in biotechnology 34, 91-97
Tissue-based map of the human proteome M Uhlén, L Fagerberg, BM Hallström, C Lindskog, P Oksvold, ... Science 347 (6220)
Reconstruction of genome-scale active metabolic networks for 69 human cell types and 16 cancer types using INIT R Agren, S Bordel, A Mardinoglu, N Pornputtapong, I Nookaew, J Nielsen PLoS Comput Biol 8 (5), e1002518
A Gene Co-Expression Network-Based Drug Repositioning Approach Identifies Candidates for Treatment of Hepatocellular Carcinoma Meng Yuan, Koeun Shong, Xiangyu Li, Sajda Ashraf, Mengnan Shi, Woonghee Kim, Jens Nielsen, Hasan Turkez, Saeed Shoaie, Mathias Uhlen, Cheng Zhang, Adil Mardinoglu Cancers 14 (6), 1573
Prediction of drug candidates for clear cell renal cell carcinoma using a systems biology-based drug repositioning approach Xiangyu Li, Koeun Shong, Woonghee Kim, Meng Yuan, Hong Yang, Yusuke Sato, Haruki Kume, Seishi Ogawa, Hasan Turkez, Saeed Shoaie, Jan Boren, Jens Nielsen, Mathias Uhlen, Cheng Zhang, Adil Mardinoglu EBioMedicine 78, 103963.
The acute effect of different NAD+ precursors included in the combined metabolic activators. Free radical biology & medicine Li, X., Yang, H., Jin, H., Turkez, H., Ozturk, G., Doganay, H. L., Zhang, C., Nielsen, J., Uhlén, M., Borén, J., & Mardinoglu, A. (2023) 205, 77–89.
Longitudinal metabolomics analysis reveals the acute effect of cysteine and NAC included in the combined metabolic activators. Yang, H., Li, X., Jin, H., Turkez, H., Ozturk, G., Doganay, H. L., Zhang, C., Nielsen, J., Uhlén, M., Borén, J., & Mardinoglu, A. (2023) Free radical biology & medicine, 204, 347–358
Discovery of drug targets and therapeutic agents based on drug repositioning to treat lung adenocarcinoma. Biomedicine & pharmacotherapy Graves, O. K., Kim, W., Özcan, M., Ashraf, S., Turkez, H., Yuan, M., Zhang, C., Mardinoglu, A., & Li, X. (2023) Biomedecine & pharmacotherapie, 161, 114486
Drug repositioning targeting glutaminase reveals drug candidates for the treatment of Alzheimer's disease patients Bayraktar, A., Li, X., Kim, W., Zhang, C., Turkez, H., Shoaie, S., & Mardinoglu, A. (2023) Journal of translational medicine, 21(1), 332
Prediction of drug candidates for clear cell renal cell carcinoma using a systems biology-based drug repositioning approach Li, X., Shong, K., Kim, W., Yuan, M., Yang, H., Sato, Y., Kume, H., Ogawa, S., Turkez, H., Shoaie, S., Boren, J., Nielsen, J., Uhlen, M., Zhang, C., & Mardinoglu, A. (2022) EBioMedicine, 78, 103963
A Gene Co-Expression Network-Based Drug Repositioning Approach Identifies Candidates for Treatment of Hepatocellular Carcinoma. Cancers Yuan, M., Shong, K., Li, X., Ashraf, S., Shi, M., Kim, W., Nielsen, J., Turkez, H., Shoaie, S., Uhlen, M., Zhang, C., & Mardinoglu, A. (2022) 14(6), 1573